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抗凝血功能化修飾的聚己內酯/殼聚糖復合小口徑人工血管研究
來源: | 作者: | 發布時間:2014-4-15 14:25:13

 抗凝血功能化修飾的聚己內酯/殼聚糖復合小口徑人工血管研究
姚瑤,孔德領,崔云,趙強
基金項目:高等學校博士學科點專項科研基金(新教師類)(20100031120021);天津市應用基礎與前沿技術研究計劃(自然科學基金)青年項目資金 (12JCQNJC09300) 作者簡介:姚瑤,1988,女,碩士研究生,小口徑人工血管 通信聯系人:趙強,1978,男,副教授,生物活性材料.

(南開大學生命科學學院生物活性材料教育部重點實驗室,天津 300071)
摘要:小口徑人工血管移植(直徑小于6mm)是治療心血管疾病的有效手段之一,但目前還沒有商品化的產品成功應用于臨床。其主要原因是血栓形成以及由此導致的血管狹窄。在本研究中,我們設計并構建了一種由合成可降解聚合物—聚(ε-己內酯)和天然聚合物—殼聚糖組成的具有復合纖維結構的小口徑人工血管(內徑2mm)。進一步,通過靜電相互作用將具有抗凝血功能的肝素分子固定在殼聚糖纖維上,從而賦予人工血管抗凝血功能。人工血管上所結合的肝素分子具有一定的穩定性,并能保持緩釋一個月以上。通過體外血小板粘附實驗、凝血實驗、考察了其血液相容性。肝素功能化修飾能夠顯著降低材料表面的血小板粘附,延長凝血時間(活化部分凝血活酶時間,APTT、血漿凝血酶原時間,PT和血漿凝血酶時間,TT),展現出良好的血液相容性。
關鍵詞:功能高分子,小口徑人工血管;肝素;緩釋;抗凝血。
中圖分類號:063-0
Anti-thrombogenic property of PCL/Chitosan hybrid small-diameter

Yao Yao, Kong Deling, Cui Yun, Zhao Qiang
(Key Laboratory of Bioactive Materials,College of Life Science, Nankai University, Tianjin,300071)
Abstract: Nowadays, vascular transplantation by using small-diameter vascular grafts is an effective strategy for the treatment of cardiovascular diseases. In clinic, no commercial product  has been successfully utilized, because the thrombus formation and the subsequent occlusion. In this study, we developed a hybrid small-diameter vascular graft from synthetic polymer poly(ε-caprolactone) (PCL) and natural polymer chitosan by co-electrospinning technique (Dinner= 2mm). Heparin was immobilized onto the grafts through ionic bonding between heparin and chitosan fibers, thus introducing anti-thrombogenic function. The immobilization was relatively stable and heparin could continuously release from the grafts for more than one month. Heparin functionalization evidently improved the haemocompatibility of the PCL/CS vascular grafts, which was illustrated by the reduced platelet adhesion and prolonged coagulation time (APTT, PT, and TT) as shown in human plasma assay.
Key words: functional polymer;Small-diameter vascular grafts; Heparin; Controlled release;  Anti-thrombogenicity

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