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大鼠腦基底動脈最適初始張力的確定
來源: | 作者: | 發布時間:2014-4-15 17:19:54

 大鼠腦基底動脈最適初始張力的確定
肖雪,平娜娜,李森,曹蕾,曹永孝
基金項目:高等學校博士學科點專項科研基金(20100201110054)

作者簡介:肖雪(1987-),女,博士生,心血管藥理學

通信聯系人:曹永孝(1957-),男,教授,心血管藥理學.

(西安交通大學醫學院藥理學系)

摘要:目的:確定SD大鼠腦基底動脈收縮的最適初始張力。方法:將大鼠腦基底動脈制成1~2 mm長的環段,用兩根鋼絲懸掛于Myograph 恒溫浴槽中。將IC1/IC100值設置為0.6~1.0,記錄其相對應的初始張力。在不同的初始張力下,記錄60 mM KCl誘導的收縮力,研究誘導的最大收縮力與初始張力的關系。結果:隨著IC1/IC100值從0.6至1.0,腦基底動脈初始張力逐漸從0.47±0.01 mN/mm 增加到2.68±0.03 mN/mm,對IC1/IC100和初始張力進行相10 關性分析,相關系數為0.95,表明二者正相關。KCl誘導的收縮力先隨IC1/IC100值升高而升高,當IC1/IC100值為0.9、初始張力為1.63 mN/mm時,KCl誘導的收縮力達到最大,其值為6.51±0.05 mN/mm,明顯高于IC1/IC100在0.6和0.7時的收縮力(P<0.05)。此后,隨著IC1/IC100值的增加,KCl誘導的收縮力不再增加,反而呈下降趨勢。結論:大鼠腦基底動脈環的最適初始張力為1.63±0.01 mN/mm。
關鍵詞:藥理學;腦基底動脈; 初始張力;肌張力描記系統;大鼠
中圖分類號:R965.2
An optimal initial tension of rat basilar artery in wire myography
XIAO Xue, PING Nana, LI Sen, CAO Lei, CAO Yongxiao
(Department of Pharmacology, Xi’an Jiaotong University College of Medicine, Xi'an 710061)
Abstract: Objective: The present study was to determine the optimal initial tension in rat basilar artery. Methods: Rat basilar arteries were cut into approximately 1~2 mm, threaded on two thin wires (40 μm in diameter), and mounted in myograph baths. Normalization procedure was carried 25 out. IC1/IC100 was set from 0.60 to 1.00, and the initial tensions were recorded. KCl 60 mM was added into the baths to induce a contractile tension. Results: The initial tension of basilar artery increased from 0.47±0.01 mN/mm to 2.68±0.03 mN/mm as the value of IC1/IC100 increased from 0.6 to 1.0. The correlation coefficient between IC1/IC100 and initial tension was 0.95. At first, the contractile tension was elevated with the value of IC1/IC100 and initial tension increasing. When 30 the IC1/IC100 and initial tension reached to 0.9 and 1.63 mN/mm, the contractile tension reached its maximum value, 6.51±0.05 mN/mm. Then the contractile tension started to decrease as IC1/IC100 or initial tension increased. The contractile tensions in IC1/IC100 value of 0.9 was significantly higher than in the IC1/IC100 value of 0.6 and 0.7 (P<0.05). Conclusion:.The most appropriate initial tension is 1.63±0.01 mN/mm.
Key words: Pharmacology; Basilar artery; Optimal initial tension; Wire myograph; Rat

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