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基于FBG 測溫的腫瘤裸鼠激光熱療實驗
來源: | 作者: | 發布時間:2014-4-15 18:03:28

基于FBG 測溫的腫瘤裸鼠激光熱療實驗
陳娜,陳少鋒,朱鴻飛,劉書朋,陳振宜
基金項目:教育部博士點新教師基金項目(20093108120017)
作者簡介:陳娜,(1982-),女,副教授,主要研究方向:光纖傳感.
(上海大學,特種光纖及光接入網省部共建重點實驗室,上海 200072)
摘要:本文將光纖布拉格光柵作為完全分布式溫度傳感器,應用在腫瘤裸鼠動物模型的激光熱療實驗中,構建了一套帶有實時溫度監控的熱療系統。該系統能夠實時獲取光纖布拉格光柵的反射譜,通過反演程序計算,得到沿光柵軸向的溫度場分布,再反饋控制輸入激光的功率大小,將腫瘤邊界的溫度始終維持在設定的溫度。實驗結果表明,經過激光熱療后,有效抑制了實驗裸鼠的腫瘤生長。
關鍵詞:溫度傳感;光纖布拉格光柵;激光熱療;完全分布式測量;動物模型;在體實驗
中圖分類號:TN249
Laser thermotherapy experiments on nude mice tumor model with FBG temperature measurement
Chen Na, Chen Shaofeng, Zhu Hongfei, Liu Shupeng, Chen Zhenyi
(The Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai University,ShangHai 200072)
Abstract: In this paper, fiber Bragg grating (FBG) is used as a fully distributed temperature sensor in laser thermotherapy. We bult a thermotherapy system with temperature measurement and control. This system can measure the FBG axial temperature distribution accurately by aquiring FBG reflection spectra in real time and calculating with spectra inversion program. With this
feedback, control temperature of tumor boundary at a certain value can be realized by varying power of laser. The experimental results show that after laser thermotherapy, the growth of tumors in nude mice have been inhibited effectively.
Keywords: temperature sensing; fiber Bragg grating; laser thermotherapy; fully distributed measurement; animal model; in vivo experiment

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