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多糖分子量與膽固醇連接臂長度對膽固醇改性普魯蘭藥物載體性質的影響
來源: | 作者: | 發布時間:2014-4-15 17:56:51

多糖分子量與膽固醇連接臂長度對膽固醇改性普魯蘭藥物載體性質的影響
張明明1,白永剛1,楊文智1,張其清1,2
基金項目:高等學校博士學科點專項科研基金(新教師基金)(20091106120051)
作者簡介:張明明,(1978-),女,助理研究員,主要研究方向:生物醫用材料,功能高分子材料。
(1. 中國醫學科學院生物醫學工程研究所,天津市生物醫學材料重點實驗室,天津 300192;2. 福州大學生物和醫藥技術研究院,福州 350108)
摘要:多糖引入疏水基團后,在水中能自組裝形成膠束,可作為疏水小分子藥物或生物活性大分子(多肽、蛋白和基因)的載體,在生物醫藥領域有著廣泛的應用價值。本文使用膽固醇為疏水配基,琥珀酸酐和己基二異氰酸酯為連接臂,對分子量為10 萬和20 萬的普魯蘭多糖進行疏水改性,制備了2 種膽固醇取代度的8 種多糖樣品,用其對阿霉素和米托蒽醌進行包封,考察了多糖分子量與膽固醇連接臂長度對藥物包封率、形態、體外釋放等性質的影響規律。
關鍵詞:普魯蘭;藥物載體;多糖分子量;連接臂
中圖分類號:R318
The influence of Pullulan molecular weight and spacer length on the property of drug carriers formed by cholesterol-modified Pullulan
ZHANG Mingming1, BAI Yonggang1, YANG Wenzhi1, ZHANG Qiqing1,2
(1. Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, TianJin 300192;2. Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, FuZhou 350108)
Abstract: This kind of micelle can be used as hydrophobic drugs or bioactive molecules carriers and has potential applications in biomedical field. In this paper, using cholesterol as hydrophobic ligand, succinic anhydride and 1,6-hexyldiisocyanate as spacers, hydrophobic modified Pullulans with molecular weight about 100,000 and 200,000 were prepared. Drug-loaded nanoparticles were then prepared by dialysis method, The influence of Pullulan molecular weight and spacer length on the loading-content, morphologies and in vitro release behaviors of drug-loading nanoparticle were then investigated in detail.
Keywords: Pullulan; drug carrier; polyssacharide molecular weight; spacer

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