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智能磁共振成像造影劑的研究進展
來源: | 作者: | 發布時間:2014-4-15 17:59:18

智能磁共振成像造影劑的研究進展
錢玉娥1,王天宇2,唐建斌2
(1. 浙江大學醫學院附屬邵逸夫醫院放射科,杭州 310027;2. 浙江大學生物納米工程中心,化學工程與生物工程學系,杭州 310027)
摘要:智能MRI 造影劑能夠對特定或者病變的一些信號如pH、金屬離子、酶、其他生物分子做出響應,改變其弛豫率。它們不僅能夠提高MRI 對病變的檢測靈敏度,而且能夠針對病變的信號分子進行分子成像。本項詳細綜述了pH、金屬離子、酶、其他生物分子等響應的智能造影劑,分析了他們的結構和響應機制及其應用前景,并對未來的研究方向做了展望。
關鍵詞:磁共振成像;造影劑;釓配合物;疾病診斷
中圖分類號:O6-1
Research Progress in Smart MRI Contrast Agent
Qian Yue1, Wang Tianyu2, Tang Jianbin2
(1. Department of Radiology, Sir Run Run Shaw Hospital (SRRSH) of School of Medicine,Zhejiang University, HangZhou 310027;2. Department of Chemical and Biological Engineering, Center for Bioengineering, Zhejiang University, HangZhou 310027)
Abstract: Smart magnetic resonance imaging (MRI) contrast agents change their relexivities upon the stimulus of pH, ion, enzyme and other biomolecules from specific or pathologic tissues. They not only improve the sensitivity of disease detection by MRI, but also make the molecular imaging of disease signal by MRI possible. This paper gives a review of smart MRI contrast agents responding to pH, ion, enzyme and other biomolecules with the focus on their structures,responding mechanism, and perspectives.
Keywords: Magnetic resonance imaging; Contrast agent; Gadolinium complexes; Disease diagnosis

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