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轉錄激活因子3 及其在腫瘤中的研究進展
來源: | 作者: | 發布時間:2014-4-15 16:24:16

轉錄激活因子3 及其在腫瘤中的研究進展
謝劍君1,謝仰民2,許麗艷3,李恩民1
基金項目:中國高等教育博士點科研基金項目新教師聯合類(20104402120005)
作者簡介:謝劍君(1979-),男,副教授,腫瘤分子生物學.

(1. 汕頭大學醫學院生物化學與分子生物學教研室,汕頭 515041;2. 汕頭大學醫學院實驗動物中心,汕頭 515041;3. 汕頭大學醫學院腫瘤病理研究室,汕頭 515041)
摘要:激活轉錄因子3(Activating Transcription Factor 3, ATF3)是堿性亮氨酸拉鏈蛋白家族中ATF/CREB亞家族的成員之一。作為一個應激早期快速反應基因,ATF3 可被一系列損傷性應激信號快速誘導表達,進而在基因轉錄、機體穩態維持、創傷愈合、細胞黏附、腫瘤形成、凋亡以及信號傳導等生理和病理過程發揮重要作用。ATF3 在腫瘤中的表達及功能具有多樣性的特點。在食管癌中,我們最近的研究表明,ATF3可能是一種腫瘤抑制基因。
關鍵詞:腫瘤;激活轉錄因子3;誘導表達;食管癌
中圖分類號:Q71; R735
Activating transcription factor 3 and its roles in tumor progression
XIE Jianjun1, XIE Yangmin2, XU Liyan3, LI Enmin1
(1. Department of Biochemistry and Molecular Biology, Medical College of Shantou University,Shantou 515041;2. Experimental Animal Center, Medical College of Shantou University, Shantou 515041;3. Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041)
Abstract: Activating Transcription Factor 3 (ATF3) is a leucine zipper-containing protein that belongs to the activating transcription factor/cAMP responsive element binding protein (ATF/CREB) family. It is an adaptive-response gene that participates in cellular processes to adapt 25 to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers. Finally, our recent studies in esophageal cancer revealed that ATF3 might be a tumor suppressor.
Key words: Cancer; ATF3; Induced-expression; Esophageal cancer

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