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整合素α5在食管鱗癌組織中的表達及其臨床意義
來源: | 作者: | 發布時間:2014-4-15 16:26:16

 整合素α5在食管鱗癌組織中的表達及其臨床意義
郭津丞1,陳博2,吳健誼1,吳智勇1,3,許秀娥2,許麗艷2,李恩民1,冉利強1,謝劍君1
基金項目:中國高等教育博士點科研基金項目新教師聯合類(20104402120005) 作者簡介:郭津丞(1989-),男,碩士研究生,腫瘤分子生物學 通信聯系人:謝劍君(1979-),男,副教授,腫瘤分子生物學.

(1. 汕頭大學醫學院生物化學與分子生物學教研室,汕頭 515041; 2. 汕頭大學醫學院腫瘤病理研究室,汕頭 515041; 3. 汕頭市中心醫院腫瘤科 汕頭 515031)
摘要:目的 研究整合素α5(Integrin α5)在食管鱗癌組織中的表達及其與臨床病理參數10 的關系。方法 應用組織芯片和免疫組織化學染色等方法,檢測了整合素α5在147例食管鱗癌組織中的表達情況并分析了其表達與臨床病理參數以及患者預后的關系。結果 1)免疫組化染色提示,在147例食管鱗癌組織中,整合素α5在癌細胞呈強染色的為34例(>5分,23.1%),弱或中等強度染色有113 例(76.9%);2)整合素α5的表達與食管鱗癌組織的分化程度顯著相關;3)整合素α5的表達水平與食管癌患者的生存率呈顯著負相關15 (P=0.005),整合素α5的表達可以作為判斷食管癌預后的獨立預警分子(P=0.003)。 結論 整合素α5可能在食管癌發生發展過程中發揮重要作用。
關鍵詞:食管鱗癌;整合素α5;患者預后
中圖分類號:R446.8

Expression of Integrin α5 in esophageal squamous cell carcinoma
GUO Jincheng1, CHEN Bo2, WU Jianyi1, WU Zhiyong1,3, XU Xiue2, XU Liyan2, LI Enmin1, RAN Liqiang1, XIE Jianjun1
(1. Department of Biochemistry and Molecular Biology, Medical College of Shantou University, 25 Shantou 515041; 2. Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041; 3. Department of Surgical Oncology, Shantou Central Hospital, Shantou 515031)
Abstract: Purpose: This study is aimed to explore the expression and the clinical significance of Integrin α5 in esophageal squamous cell carcinoma (ESCC). Methods: Integrin α5 expression was 30 evaluated using tissue microarray and immunohistochemical staining in 147 samples of human ESCC. Impact of Integrin α5 expression on the survival of ESCC patients was also determined. Results: Integrin α5 was high-expression in 23.1% (34/147) of the ESCC samples and was weak or moderate-expression in the other 113 cases. Integrin α5 expression was associated with differentiation of ESCC. Moreover, high tumorous Integrin α5 expression was significantly 35 correlated with shorter overall survival and Multivariate Cox regression analysis revealed that Integrin α5 expression was an independent prognostic factor for human ESCC patients. Conclusions: Integrin α5 is an ESCC candidate clinical prognostic marker and a potential treatment target.
Key words: esophageal squamous cell carcinoma; Integrin α5; prognostic factor

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