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免疫球蛋白受體作為藥物靶點的研究進展
來源: | 作者: | 發布時間:2014-4-15 17:03:23

免疫球蛋白受體作為藥物靶點的研究進展
黃瓊1,陳文生2,吳育晶2,魏偉2
基金項目:高等學校博士學科點專項科研基金(20113420120006, 20123420110003)
作者簡介:黃瓊(1980-),女,副教授,研究方向:臨床藥理學
通信聯系人:魏偉,男,教授,博士研究生導師,研究方向:臨床藥理學.

(1. 安徽醫科大學臨床藥理研究所,合肥 230032;2. 安徽醫科大學臨床藥理研究所,合肥 230032)
摘要:免疫球蛋白(Immunoglobulin, Ig)又稱為抗體,是體內體液免疫的重要組成部分。Ig 與免疫球蛋白受體(immunoglobulin receptor, IgR)結合觸發相應的生物學活性。不同的Ig 亞型有不同的生物學功能,且IgR 可作為炎癥免疫相關疾病的治療靶點,本文綜述了IgR 功能及在炎癥免疫相關疾病治療與藥物研究中的作用。
關鍵詞:免疫球蛋白受體;功能;炎癥;治療
中圖分類號:R967 免疫藥理學
Progress in the study of a new therapeutic target:immunoglobulin receptors
HUANG Qiong1, CHEN Wensheng2, WU Yujing2, WEI Wei2
(1. Institute of Clinical Pharmacology, Anhui Medical University,Hefei, P.R. China 230032;2. Institute of Clinical Pharmacology, Anhui Medical University, Hefei, P.R. China 230032)
Abstract: Immunoglobulins (Ig), also called antibodies, are important components in humoral-mediated immunity. Ig can bind with their receptors, called immunoglobulin receptors  (IgR), trigger biologic activity respectively. Different subtypes of Igs show different function. And IgRs have been treated as therapeutic targets in inflammation and immunity related diseases for many years. This article reviewed the recent progresses in the study of IgR function and its therapeutic role in inflammation and immunity related diseases.
Key words: immunoglobulin receptor; function; inflammation; therapy

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