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PD-1 在慢性HCV 感染者CD4+T 細胞不同亞群中的表達
來源: | 作者: | 發布時間:2014-4-15 17:01:56

PD-1 在慢性HCV 感染者CD4+T 細胞不同亞群中的表達
沈弢,鄭佳佳
基金項目:教育部2010 年度高等學校博士點專項科研基金(20100001120047)
作者簡介:沈弢(1791-),男,副教授,主要研究方向為病毒學和免疫學.

(北京大學醫學部基礎醫學院病原生物學系)
摘要:目的 分析PD-1 在慢性HCV 感染者CD4+T 細胞亞群的表達情況,以及PD-1 表達水平與HCV 血漿病毒載量和酶學指標的相關性。 方法 采用流式細胞術對19 例慢性HCV 感染者和17 例健康對照者進行了外周血CD4+T 細胞亞群和表型分析,及各細胞亞群PD-1 表達水平的測定。同時將細胞亞群的比例,PD-1 表達水平與HCV 病毒學指標及酶學指標進行了關聯性分析。 結果 慢性HCV 感染者Naïve T 細胞明顯低于健康對照者,而TEM 細胞和終末效應T 細胞明顯高于健康對照者。PD-1 在慢性HCV 感染者中各CD4+T 細胞亞群和總CD4+T 細胞中的表達水平升高。慢性HCV 感染者PD-1 表達水平升高與HCV 病毒學指標及酶學指標之間無明顯相關性。 結論 本研究系統分析了HCV 長期慢性感染者體內外周血CD4+T 細胞亞群分布特征。結果顯示分析患者外周血CD4+T 細胞表面成熟和活化抑制標志對評價宿主細胞免疫水平提供了一個很好的參考指標。
15 關鍵詞:基礎醫學;PD-1;Naïve T 細胞;TCM 細胞;TEM 細胞;效應T 細胞
中圖分類號:[R394.5]
The study of PD-1 expression on different CD4+T cell subsets in chronic HCV infected patients
Tao Shen1, Jiajia Zheng2
(1. Department of Microbiology, Peking University Health Science Center;2. Department of Microbiology,Peking University Health Science Center)
Abstract: Objective To evaluate the PD-1 expression on different CD4+T cell subsets in chronic HCV infected patients, and investigate the correlation of PD-1 abnormal activating expression on 25 CD4+T cell with HCV virological and enzymological indicators. Methods A study of the percentage of CD4+T cell subsets and MFI of PD-1 expression on total CD+T cells and its subsets were performed by multi-parameter flow cytometry in 19 chronic HCV infected individuals and 17 healthy control volunteers. Additionally, we studied the correlations between PD-1 expression and HCV Virological and enzymological indicators. Results The percentage of Naïve T cell subsets was lower but TEM and Effector T cell subsets were higher in 19 chronic HCV infections compared to healthy control. The level of PD-1 in total CD4+T cells and four CD4+T cell subsets
increased dramatically in chronic HCV infections. There was no significant difference between the upregulation of PD-1 and the HCV virological and enzymological indicators. Conclusion The distributional pattern of peripheral CD4+T cell subsets and the characteristics of PD1 expression on CD4+ T cells in chronic HCV infected patients were investigated. The finding indicated that it was meaningful to evaluate the status of host cellular immune response through monitoring maturation (CD45RA and CD27) and inactivation marker PD-1 on peripheral CD4+T cells and its subsets in chronic HCV infected patients.
Key words: k Basic medicine; PD-1; Naïve T cells; TCM; TEM; Effector T cells

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