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表皮葡萄球菌色氨酰-tRNA合成酶抑制劑W-23的抗菌活性研究
來源: | 作者: | 發布時間:2014-4-15 14:32:58

表皮葡萄球菌色氨酰-tRNA合成酶抑制劑W-23的抗菌活性研究
吳旸,毛嘉琳,瞿滌
基金項目:教育部博士點基金新教師類(20100071120049) 作者簡介:吳旸(1981-),男,講師,研究方向:病原生物學 通信聯系人:瞿滌(1951-),女,教授,研究方向:醫學微生物學.

(復旦大學上海醫學院醫學分子病毒學教育部/衛生部重點實驗室,上海 200032)
摘要:目的 檢測色氨酰-tRNA合成酶抑制劑W-23對葡萄球菌的抗菌活性。方法 采用肉湯稀釋方法檢測W-23對葡萄球菌、大腸桿菌的最低抑菌濃度MIC,并檢測其與氨芐青霉素或氯霉素聯用對表皮葡萄球菌的聯合抗菌效果。結果 化合物W-23對表皮葡萄球菌和金黃色葡萄球菌的MIC為2-4微克/毫升,抗菌類型屬于抑菌劑,與氨芐青霉素聯用對耐甲氧西林表皮葡萄球菌具有協同抗菌作用。結論 W-23對葡萄球菌具有較強的抗菌活性,具有潛在應用價值。
關鍵詞:病原生物學;葡萄球菌;色氨酰-tRNA合成酶;抑制劑
中圖分類號:R3

Antibacterial activity of a new inhibitor of Staphylococcus epidermidis tryptophanyl-tRNA synthetase
WU Yang, MAO Jialin, QU Di
(Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical School of Fudan University, Shanghai 200032)
Abstract: Objective: Investigate the antibacterial activity of W23, a new inhibitor of Staphylococcus epidermidis tryptophanyl-tRNA synthetase. Methods: Determine the Minimal Inhibitory Concentration of W-23 to Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli; detect the effect of W-23 in combination with Ampicillin or Chloramphenicol on S. epidermidis growth. Results: The MIC of W-23 to Staphylococcus species is about 2-4 μg/ml.  W-23 is a bacteristatic agent. Combination of W-23 and ampicillin has synergistic effect on growth of methicillin-resistent Staphylococcus epidermidis. Conclusion: W-23 has potent antibacterial activity against Staphylococcus and has a potential value in new drug development.
Key words: Medical Microbiology; Staphylococcus; tryptophanyl-tRNA synthetase;inhibitor

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