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小分子化合物誘導胚胎干細胞定向分化的研究
來源: | 作者: | 發布時間:2014-4-15 16:49:57

小分子化合物誘導胚胎干細胞定向分化的研究
孟祥智,周唯,劉艷華,李宗金,范艷
基金項目:教育部高等學校博士學科點專項科研基金(20100031120044);中央高;究蒲袠I務費專項資金(65011251);國家自然科學基金(81200158) 作者簡介:孟祥智(1988-),女,研究生在讀,主要研究方向:腫瘤干細胞 通信聯系人:范艷(1982-),女,講師,主要研究方向:醫學化學.

(南開大學醫學院,天津,300071)
摘要:胚胎干細胞具有無限增殖、自我更新和多向分化的特性,能被誘導分化為所有類型的細胞。將產生的細胞用于替代治療具有非常重要的意義。外源性的小分子化合物能夠有效誘導胚胎干細胞的定向分化,并且具有結構簡單、易于設計合成、調節作用單一等優點,為胚胎干細胞的定向分化提供了一個有效的化學工具。本文綜述了小分子化合物誘導胚胎干細胞分化方面的研究。
關鍵詞:胚胎干細胞;小分子化合物;誘導;分化
中圖分類號:R313
A chemical approach to inducing differentiation of 15 embryonic stem cells
Meng Xiangzhi, Zhou Wei, Liu Yanhua, Li Zongjin, Fan Yan
(Medical School of Nankai University, TianJin 300071)
Abstract: Embryonic stem cells (ES) represent potentially unlimited source for all types of specialized cells and are ideally suited for studies of differentiation and early embryonic development. They may provide an unlimited cell source for cell replacement therapy. This requires an improved ability to manipulate stem cell differentiation. Several small molecules have been recently identified that can be used to selectively control ES cell fate. The development of chemical approach provides various functional small molecules for stem cell differentiation. In this review, how small molecule compounds regulate direct differentiation of stem cells is presented.
Key words: Embryonic stem cell; Small molecule; Induce; Differentiation

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